Research library / Compounds
A nine-residue peptide first isolated in 1977, still an unresolved riddle.
DSIP, short for delta sleep-inducing peptide, is a nine-amino-acid peptide: Trp–Ala–Gly–Gly–Asp–Ala–Ser–Gly–Glu. Researchers in Basel isolated it in 1977 during sleep research in rabbits. How the body makes and senses it is still debated; a 2006 review called it an unresolved riddle. Prism Labs supplies it as a lyophilized vial.
01
What is DSIP made of?
The sequence of DSIP is WAGGDASGE. The reference record lists the formula C35H48N10O15 and a molecular weight of 848.8 g/mol (PubChem CID 68816).
The name comes from delta waves, the slow brain waves of deep sleep, which the original experiments recorded.
Sources: [3] PubChem · reference structure · [1] PNAS · 1977
02
Where to buy DSIP
DSIP is sold direct by Prism Labs at prismlabs.store, in 10mg vials at $39.99 per vial. The latest published lab report, tested October 26, 2026, measured 99.73% purity. Every lot’s certificate of analysis is on the product page, with a link to verify it with the testing lab.
Orders placed before 4:30 PM CT ship the same day, seven days a week, when the size is in stock. Standard shipping is free over $125. Packs of 2 or more vials are discounted, up to 18% off.
See DSIP sizes, prices and lab reports · How to vet any peptide supplier
03
Where did DSIP come from?
In 1977, a Basel group including Guido Schoenenberger and Marcel Monnier reported a peptide from the blood of rabbits in which sleep had been induced, and linked it to delta-wave activity in recipient animals.
The next year they published its amino-acid sequence and a synthetic version. Reviews followed in 1984 and 1986 as interest grew.
Sources: [1] PNAS · 1977 · [2] Experientia · 1977 · [4] Pflügers Archiv · 1978 · [5] Neuroscience & Biobehavioral Reviews · 1984 · [6] Peptides · 1986
04
What is and isn’t known
DSIP has an unusual status: studied for decades, yet still unsettled.
- No gene encoding it and no specific receptor had been identified, according to a 2006 review.
- Studies have examined it in sleep, stress-hormone and circadian research, mostly in animals.
- Findings have varied between laboratories, which is part of why reviews describe it as unresolved.
These are observations in laboratory models. They are not evidence about any use in people.
Sources: [7] Journal of Neurochemistry · 2006 · [5] Neuroscience & Biobehavioral Reviews · 1984
05
How is DSIP supplied and stored?
DSIP ships as a lyophilized (freeze-dried) powder in 10 mg vials. The powder is stable at room temperature in transit. For lab use it is reconstituted with bacteriostatic water such as Prism H2O.
For a vial, concentration is content divided by volume: 10 mg in 2 mL gives 5 mg per mL. The reconstitution calculator handles other combinations.
For storage before and after reconstitution, see how to store lyophilized peptides.
06
How do I verify DSIP batches?
Every lot has its own certificate of analysis from an independent lab. Read three results separately:
- Identity: confirms the expected compound was detected.
- Purity: the share of the measured material that is the intended compound.
- Content: the amount measured, compared with the label.
Then match the lot number on your vial or bottle to the report, and use the report’s verification link to confirm it with the testing lab. Step by step: how to read a peptide COA.
A little more clarity
Questions, answered
What is DSIP peptide?
Delta sleep-inducing peptide: a nine-amino-acid peptide (WAGGDASGE) isolated in 1977 during sleep research in rabbits.
Where can I buy DSIP?
From Prism Labs at prismlabs.store, in 10mg vials at $39.99 per vial. Each lot’s certificate of analysis is published on the product page.
What does DSIP stand for?
Delta sleep-inducing peptide, named after the delta brain waves the first experiments recorded.
Is the DSIP receptor known?
No specific receptor or gene had been identified as of a 2006 review, which called the peptide an unresolved riddle.
Does DSIP come as a nasal spray?
No. Prism Labs supplies it as a 10 mg lyophilized vial, each lot with its own COA. How the two formats differ in general: peptide nasal spray vs vial.
Is it for human use?
No. Prism Labs sells it for laboratory research use only.
Follow the evidence
Sources & reading notes
Open the original record for its methods and limitations. The sources below do not certify the supplied product or its finished formulation.
- PNAS · 1977 ↗
Original characterization of the peptide.
- Experientia · 1977 ↗
Compares the original and synthetic nonapeptide.
- PubChem · reference structure ↗
The structure referenced in the product specifications; not a measurement of the supplied batch.
- Pflügers Archiv · 1978 ↗
Amino-acid sequence and synthesis.
- Neuroscience & Biobehavioral Reviews · 1984 ↗
Early review.
- Peptides · 1986 ↗
Review update.
- Journal of Neurochemistry · 2006 ↗
Review of what remained unknown.
Prepared by Prism Labs from the linked source records and public product documentation. Research context only; not a preparation protocol or a claim about outcomes. Send a source correction.




