Research library / Compounds
Four amino acids, designed in St. Petersburg from the composition of a pineal-gland extract.
Epitalon is a synthetic tetrapeptide: alanine, glutamic acid, aspartic acid and glycine (AEDG). A St. Petersburg research group designed it from the amino-acid composition of epithalamin, a peptide extract of the pineal gland, and has studied it in aging research ever since. Prism Labs supplies it as a 10 mg lyophilized vial.
01
What is Epitalon made of?
The sequence of Epitalon is Ala–Glu–Asp–Gly, written AEDG in one-letter code. The reference record lists the formula C14H22N4O9 and a molecular weight of 390.35 g/mol (PubChem CID 219042).
At four residues it is one of the smallest peptides in the catalog, alongside the three-residue KPV and Glutathione.
Sources: [1] PubChem · reference structure
02
Where to buy Epitalon
Epitalon is sold direct by Prism Labs at prismlabs.store, in 10mg vials at $44.99 per vial. The latest published lab report, tested October 26, 2026, measured 99.70% purity. Every lot’s certificate of analysis is on the product page, with a link to verify it with the testing lab.
Orders placed before 4:30 PM CT ship the same day, seven days a week, when the size is in stock. Standard shipping is free over $125. Packs of 2 or more vials are discounted, up to 18% off.
See Epitalon sizes, prices and lab reports · How to vet any peptide supplier
03
Where did Epitalon come from?
Epitalon came out of the Saint Petersburg Institute of Bioregulation and Gerontology, where Vladimir Khavinson’s group made peptide preparations from animal tissues. One of them, epithalamin, was extracted from the pineal gland.
From the amino-acid composition of those extracts, the group designed short synthetic peptides. AEDG was the one designed for the pineal gland, and the group’s 2002 overview reports that it reproduced effects of the extract in their models.
A 2025 overview from a Warsaw team, independent of the original group, summarizes 25 years of in vitro, animal and computational studies.
Sources: [2] Neuroendocrinology Letters · 2002 · [3] International Journal of Molecular Sciences · 2025
04
What has Epitalon been studied for?
Most of the literature comes from cells and animals, and much of it from the originating group:
- Lifespan and tumor development in transgenic mice, in a 2002 study.
- Melatonin and other hormone rhythms in old rhesus monkeys, in a 2005 study.
- Telomere length and telomerase activity in human cell lines, in a 2025 study that found different mechanisms in normal and cancer cells.
When a field depends heavily on one group, independent replication is the thing to look for. The 2025 cell study came from a separate laboratory in London.
These are observations in laboratory models. They are not evidence about any use in people.
Sources: [4] Bulletin of Experimental Biology and Medicine · 2002 · [5] Experimental Gerontology · 2005 · [6] Biogerontology · 2025
05
Is Epitalon FDA-approved?
No. Epitalon is not an FDA-approved drug. In October 2026, HHS said it does not intend to act against state-licensed pharmacies and licensed physicians that compound it for a patient with a prescription, under set conditions. That is not approval, and it does not cover research-use vials like ours. Details: what the HHS peptide policy changed.
06
How is Epitalon supplied and stored?
Epitalon ships as a lyophilized (freeze-dried) powder in 10 mg vials. The powder is stable at room temperature in transit. For lab use it is reconstituted with bacteriostatic water such as Prism H2O.
Concentration is content divided by volume: 10 mg in 2 mL gives 5 mg per mL. The reconstitution calculator handles other combinations.
For storage before and after reconstitution, see how to store lyophilized peptides.
07
How do I verify Epitalon batches?
Every lot has its own certificate of analysis from an independent lab. Read three results separately:
- Identity: confirms the expected compound was detected.
- Purity: the share of the measured material that is the intended compound.
- Content: the amount measured, compared with the label.
Then match the lot number on your vial or bottle to the report, and use the report’s verification link to confirm it with the testing lab. Step by step: how to read a peptide COA.
A little more clarity
Questions, answered
What is Epitalon?
A synthetic four-amino-acid peptide, Ala–Glu–Asp–Gly (AEDG), designed from the composition of a pineal-gland extract and studied in aging research.
Where can I buy Epitalon?
From Prism Labs at prismlabs.store, in 10mg vials at $44.99 per vial. Each lot’s certificate of analysis is published on the product page.
What is epithalamin?
A peptide extract of the pineal gland made by the St. Petersburg group. The synthetic tetrapeptide was designed from its amino-acid composition.
Is Epitalon a peptide?
Yes. It is a tetrapeptide, a chain of four amino acids.
What does AEDG mean?
The one-letter codes of its four amino acids: alanine, glutamic acid, aspartic acid and glycine.
Is it for human use?
No. Prism Labs sells it for laboratory research use only.
Follow the evidence
Sources & reading notes
Open the original record for its methods and limitations. The sources below do not certify the supplied product or its finished formulation.
- PubChem · reference structure ↗
Ala-Glu-Asp-Gly; not a measurement of the supplied batch.
- Neuroendocrinology Letters · 2002 ↗
Overview by the St. Petersburg group that designed the tetrapeptide.
- International Journal of Molecular Sciences · 2025 ↗
Independent overview of in vitro, animal and computational studies.
- Bulletin of Experimental Biology and Medicine · 2002 ↗
Lifespan and tumor development in transgenic mice.
- Experimental Gerontology · 2005 ↗
Hormone rhythms in old and young rhesus monkeys.
- Biogerontology · 2025 ↗
Telomere length and telomerase in normal and cancer cell lines.
Prepared by Prism Labs from the linked source records and public product documentation. Research context only; not a preparation protocol or a claim about outcomes. Send a source correction.




