What is NAD+?

01

What is NAD+ made of?

The name describes the structure: two nucleotides, one carrying nicotinamide and one carrying adenine, joined through their phosphate groups. It is a coenzyme, a small helper molecule that enzymes need, not a chain of amino acids.

The “+” marks the oxidized form. When it accepts electrons it becomes NADH, and the pair shuttles electrons from one reaction to the next. The reference record for the oxidized form lists C21H27N7O14P2 and 663.4 g/mol (PubChem CID 10897651).

Sources: [1] PubChem · oxidized reference structure · [2] Science · 2015

02

Where to buy NAD+

NAD+ is sold direct by Prism Labs at prismlabs.store, in 500mg and 1000mg vials from $44.99 per vial. The latest published lab report, tested October 26, 2026, measured 99.85% purity. Every lot’s certificate of analysis is on the product page, with a link to verify it with the testing lab.

Orders placed before 4:30 PM CT ship the same day, seven days a week, when the size is in stock. Standard shipping is free over $125. Packs of 2 or more vials are discounted, up to 18% off.

See NAD+ sizes, prices and lab reports · How to vet any peptide supplier

03

What it does in cells

A 2015 review describes two jobs:

• Electron carrier: it moves electrons between the oxidation–reduction (redox) reactions of metabolism.
• Co-substrate: enzymes such as the sirtuins and PARPs consume it as they work, so cells must keep making more.

The second role ties it to sirtuin research. A 2001 study showed that the sirtuin SIRT1 needs it to remove acetyl groups from the protein p53.

Sources: [2] Science · 2015 · [3] Cell · 2001

04

What has NAD+ been studied for?

A large literature, mostly in cells and animals, covers:

• How cellular levels change with age, reviewed in 2014 and 2021.
• Sirtuins and other enzymes that depend on it.
• The pathways cells use to make and recycle it.

These are observations in laboratory models. They are not evidence about any use in people.

Sources: [4] Trends in Cell Biology · 2014 · [5] Nature Reviews Molecular Cell Biology · 2021 · [2] Science · 2015

05

Why it sits in a peptide catalog

NAD+ is not a peptide, but it is handled like one in the lab: it ships as a lyophilized powder, it is reconstituted with bacteriostatic water, and each lot has its own certificate of analysis.

Related reading: What is 5-amino-1MQ?, a small molecule aimed at an enzyme in nicotinamide metabolism.

06

How is NAD+ supplied and stored?

NAD+ ships as a lyophilized (freeze-dried) powder in 500 mg or 1000 mg vials. The powder is stable at room temperature in transit. For lab use it is reconstituted with bacteriostatic water such as Prism H2O.

Concentration is content divided by volume: 500 mg in 5 mL gives 100 mg per mL. The reconstitution calculator handles other combinations.

For storage before and after reconstitution, see how to store lyophilized peptides.

07

How do I verify NAD+ batches?

Every lot has its own certificate of analysis from an independent lab. Read three results separately:

• Identity: confirms the expected compound was detected.
• Purity: the share of the measured material that is the intended compound.
• Content: the amount measured, compared with the label.

Then match the lot number on your vial or bottle to the report, and use the report’s verification link to confirm it with the testing lab. Step by step: how to read a peptide COA.