What is Sermorelin?

01

What is Sermorelin made of?

Sermorelin is a single chain of 29 amino acids, YADAIFTNSYRKVLGQLSARKLLQDIMSR, identical to the start of the 44-amino-acid human hormone. Like the hormone, it ends in an amide (–NH2). Nothing else is changed: no added groups and no substituted amino acids.

The reference record lists the formula C149H246N44O42S and a molecular weight of about 3,358 g/mol (PubChem CID 16132413). Papers also write it as GHRH(1–29) or GRF(1–29), from the hormone’s older name, growth hormone-releasing factor.

Sources: [1] PubChem · reference structure · [2] Science · 1982 · [3] Biochemical and Biophysical Research Communications · 1984

02

Where to buy Sermorelin

Sermorelin is sold direct by Prism Labs at prismlabs.store, in 10mg vials at $64.99 per vial. The latest published lab report, tested October 26, 2026, measured 99.83% purity. Every lot’s certificate of analysis is on the product page, with a link to verify it with the testing lab.

Orders placed before 4:30 PM CT ship the same day, seven days a week, when the size is in stock. Standard shipping is free over $125. Packs of 2 or more vials are discounted, up to 18% off.

See Sermorelin sizes, prices and lab reports · How to vet any peptide supplier

03

Where did Sermorelin come from?

The parent hormone of Sermorelin was identified in 1982 in a pancreatic tumor that had caused acromegaly, a condition of excess growth hormone. Roger Guillemin’s group reported the 44-amino-acid sequence and showed that a synthetic copy was fully active.

Chemists then trimmed the chain from its far end. In 1984 rat pituitary-cell experiments, the 1–29 amide kept about half the full hormone’s potency. Shorter fragments still worked, but only at far higher amounts, and at 19 residues activity vanished.

A 1999 review called the 1–29 fragment the shortest synthetic peptide with the full biological activity of GHRH.

Sources: [2] Science · 1982 · [3] Biochemical and Biophysical Research Communications · 1984 · [4] BioDrugs · 1999

04

A template for other analogues

In plasma, an enzyme called dipeptidyl peptidase IV (DPP-IV) cuts GHRH between its second and third amino acids. A 1989 study found the same cut in the 1–29 amide, and that swapping either of the first two amino acids for its mirror-image (D-) form blocked it.

CJC-1295 was built on this template: four amino acids substituted, plus, in the 2005 paper that introduced it, a group that binds albumin in the blood, called DAC. The versions with and without DAC are separate compounds.

Its blend with Ipamorelin: What is CJC-1295 / Ipamorelin?

Sources: [5] Journal of Clinical Investigation · 1989 · [6] Endocrinology · 2005 · [7] Drug Testing and Analysis · 2021

05

Sermorelin vs Tesamorelin

Tesamorelin keeps all 44 amino acids and adds a small chemical group to the first; Sermorelin stops at 29.

Side by side: Tesamorelin vs Sermorelin, compared. Full profile: What is Tesamorelin?

Sources: [2] Science · 1982

06

What has Sermorelin been studied for?

The literature on Sermorelin runs from 1980s peptide chemistry to modern drug testing:

• How chain length changes growth hormone release from rat pituitary cells.
• Clinical studies of pituitary growth hormone release, reviewed in 1999.
• Anti-doping detection of four GHRH analogues and their breakdown products in urine, including this peptide minus its first two amino acids (2021).

These are observations in laboratory models. They are not evidence about any use in people.

Sources: [3] Biochemical and Biophysical Research Communications · 1984 · [4] BioDrugs · 1999 · [7] Drug Testing and Analysis · 2021

07

How is Sermorelin supplied and stored?

Sermorelin ships as a lyophilized (freeze-dried) powder in 10 mg vials. The powder is stable at room temperature in transit. For lab use it is reconstituted with bacteriostatic water such as Prism H2O.

Concentration is content divided by volume: 10 mg in 2 mL gives 5 mg per mL. The reconstitution calculator handles other combinations.

For storage before and after reconstitution, see how to store lyophilized peptides.

08

How do I verify Sermorelin batches?

Every lot has its own certificate of analysis from an independent lab. Read three results separately:

• Identity: confirms the expected compound was detected.
• Purity: the share of the measured material that is the intended compound.
• Content: the amount measured, compared with the label.

Then match the lot number on your vial or bottle to the report, and use the report’s verification link to confirm it with the testing lab. Step by step: how to read a peptide COA.